VAG Forte™ - Research Brief
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||I Recommended Use
||I Clinical Trials
||I Research Brief
60 tablets/30 days
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Ingredients (per 1 tablet):
VAG Forte™ - Research Brief:
The main active ingredient of VAG Forte™ is Black cohosh (Cimicifuga foetida) standardized root extract with 8% of triterpene glycosides (as 27-deoxyactein).
Black cohosh is a perennial herb, a member of the buttercup family that has a long history of traditional use in North American Indian medicine and has been used widely in Western cultures since the early 1800s. It is generally used for the relief of the symptoms of menopause.
Cimicifuga was traditionally used by the Cherokee and Iroquois nations for general malaise, gynecopathy (diseases peculiar to women), kidney ailments, malaria, rheumatism, and sore throat. Cimicifuga was used by American colonists for amenorrhea, bronchitis, chorea, dropsy, fever, hysteria, itch, lumbago, malaria, nervous disorders, snakebite, uterine disorders, and yellow fever.
Black cohosh came into general use around 1850 in the U.S., becoming one of the most popular remedies, and was given a prominent place in the Eclectic Dispensary published in 1852. It was used specifically for rheumatoid muscular pains, menstrual pain, neuralgic pain, headache, and inflammation. (1) First scientific research of Black cohosh’s properties was done in the beginning of the twentieth century. Using methods existing at that time, scientists discovered the following chemical ingredients in the root of Black cohosh: phytosterol, a salicylic acid, sugar, tannins and fatty acids. In the research conducted in 1944, estrogen-like properties of black cohosh have been detected for the first time in the experiment on mice.
Glycosides, such as actein and 27-deoxyactein, – the active components with positive influence on female reproductive system - have been identified in 50 and 60th of the last century. It is accepted, that black cohosh’s biological activity depends not on one substance, but on synergistic effect of several active components of this plant.
Black cohosh contains several ingredients, including triterpene glycosides (actein and 27-deoxyactein) and isoflavones (formononetin). Other constituents include aromatic acids, tannins, resins, fatty acids, starches, and sugars. As a woman approaches menopause, the signals between the ovaries and pituitary gland diminish, slowing down estrogen production and increasing luteinizing hormone (LH) secretions. Hot flashes can result from these hormonal changes.
In the mid 50th of the last century black cohosh became popular menopause relief remedy in Germany, owing to numerous scientific certificates and clinical researches. The German scientists anxiously searched for an alternative to hormone-replacement therapy, which by then has shown serious side-effects in many patients, have declared that the black cohosh extract is effective for reduction of menopause symptoms. In Germany by 1962 the results of at least 14 clinical researches with 1500 participants were published (though in modern understanding, it is impossible to consider these researches controllable). A review of eight clinical trials found black cohosh to be both safe and effective for symptomatic relief of menopausal hot flashes, and other symptoms which improved included night sweats, insomnia, nervousness, and irritability.
Clinical researches have shown, that black cohosh possesses estrogen-like properties. The reduction in an estrogen level during menopause causes changes in a female body and such unpleasant symptoms as hot flashes, mood changes and sleeplessness. Hormone-replacement therapy decreases these symptoms, but increases risk of cancer and cardiovascular diseases. Black cohosh application does not have such side effects.
The American college of Obstetrics and Gynecology recommends to use Black cohosh extract (no more than 6 months at a time) to decrease the menopause symptoms, especially such, as sleep disorders, hot flashes, mood changes. (2)
Owing to the efficiency, Black cohosh takes a special place among the herbs beneficial for female health.