Sanoprost™ - Research Brief
|I Product Info||I Ingredients
||I Recommended Use
||I Clinical Trials
||I Research Brief
Indication: prophylaxis and maintenance of normal prostate health, urination disturbance, urinary retention and urinary tract infections, hyperplastic process in prostate, decreased sexual activity, deterioration in sperm quality.
Actions: designed to maintain prostate health, relieves Benign Prostatic Hyperplasia (BPH) and prostatitis symptoms, provides antiseptic action, helps increase the volume and peak urine flow, decrease residual urine volume, helps increase sexual activity in men, provides durable action effect.
Ingredients (per one tablet): Saw palmetto (Serenoa repens) berries extract (8:1) (90% total sterols and free fatty acids) (equivalent to 1280 mg of crude herb) – 160 mg; Pygeum (Prunus Africana) bark extract (4:1) (25% total sterols) (equivalent to 200 mg of crude herb) - 50 mg; Stinging nettle (Urtica Dioca) root extract (25:1) (equivalent to 3000 mg of crude herb) - 120 mg.
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Sanoprost™ - Research Brief:
Saw Palmetto promotes prostate health by decreasing the metabolism and action of male steroids. Saw Palmetto has been demonstrated to decrease the activity of 5-alpha reductase which stimulates the conversion of testosterone to dihydrotestosterone (DHT), its more active form. (6) Since DHT is necessary for excessive growth (hyperplasia) of the prostate and is elevated in men with BPH, inhibition of 5-alpha reductase, and therefore DHT production, may alleviate BPH and associated compression of the urethra (the tube that runs through the prostate gland to carry urine from the bladder). Additionally, studies have shown that Saw Palmetto helps to inhibit the production of various inflammatory factors, thus serving to decrease overall prostate inflammation.
Clinical studies have used a dosage of 160 mg twice daily or 320 mg once daily of a lipophilic extract containing 80 to 90 percent total sterols and free fatty acids. A daily dosage of 480 mg was not found to be any more effective in a six-month study of dosages.
Animal studies indicate that partial outlet obstruction to the bladder may lead to bladder contractile problems. In rabbit study, BPH-like symptoms were prevented by pre-treatment with Pygeum extract. The action of Pygeum may be protecting the bladder against lack of oxygen caused by or as a result of injury.
The accepted form of Pygeum used in Europe for treatment of BPH is a lipophilic extract standardized to 13% total sterols. Men with mild to moderate BPH sometimes take 50-100 mg two times per day. A double-blind trial found that 100 mg once daily was as effective as 50 mg twice per day.
The root of stinging nettle contains scopoletin, sterols, fatty acids, polysaccharides and isolectins. Several of nettle’s lectin chemicals have demonstrated marked antiviral actions. Other chemicals (flavonoids in the leaves and a lectin in the root) have been documented with interesting immune stimulant actions in preliminary research.
The last area of research on nettle focuses on its usefulness for prostate inflammation (prostatitis) and benign prostate hyperplasia (BPH). In more than 20 clinical studies thus far, nettle root (and nettle combined with other herbs) has demonstrated an improvement of clinical symptoms in BPH and prostatitis. While nettle’s benefit for prostatitis is related to its documented anti-inflammatory properties demonstrated in the arthritis and rhinitis research, the effect of nettle on BPH is different—it works on a hormonal level.
Some of the more recent research on BPH and nettles indicates that nettle can interfere with or block a number of hormone-related chemical processes in the body that are implicated in the development of BPH. In clinical research, nettles have demonstrated the ability to stop the conversion of testosterone to dihydrotestosterone (by inhibiting an enzyme required for the conversion).
It all sounds a bit complicated, but basically, most all of the complex intercellular processes required to trigger the prostate to grow new cells and enlarge seem to be inhibited by nettle.
This is great news for men suffering from BPH (and there are millions)! Human and animal studies have confirmed these effects and benefits.