Reglucol™ - Research Brief

I Product Info I Ingredients
I Recommended Use
I Clinical Trials
I Research Brief
I References



Indication: obesity, dysbolism, chronic fatigue, increased glucose level; to increase lean muscle mass in sportsmen.

Actions: helps normalize blood glucose levels, decreases sugar cravings, helps decrease blood cholesterol levels, improves the cardiac muscle nourishment, helps normalize body weight, promotes fat burning.

Ingredients(per one capsule): Chromium (as chromium + GPM™) - 50 mcg; Gymnema sylvestre leaf extract 6:1 (25% gymnemic acids) (equivalent to 1200 mg of crude herb) - 200 mg; Banaba (Lagerstroemia speciosa) leaf extract 20:1 (1% corosolic acid) (equivalent to 320 mg of crude herb) - 16 mg.

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Reglucol™ - Research Brief:


Chromium is a mineral that humans require in trace amounts. It is found primarily in two forms:  trivalent (chromium 3+), which is biologically active and found in food, and hexavalent (chromium 6+), a toxic form that results from industrial pollution.


Low chromium levels can increase blood sugar, triglycerides, cholesterol levels, and increase the risk for a number of conditions, such as diabetes and heart disease.


Chromium, the essential mineral once believed to be toxic, is in fact essential to health. In the mid-twentieth century, scientists put laboratory rats on a diet devoid of chromium. The rodents quickly developed glucose intolerance, a condition that often precedes the development of Type II diabetes in humans. Researchers then switched the animals’ feed to brewer’s yeast—a rich, natural source of chromium—and the rats’ health promptly returned to normal.


In 1957, researchers discovered a compound extracted from pork kidney called glucose tolerance factor (GTF). Chromium was later identified as the active component of GTF. Administration of GTF helped diabetic rats use insulin more efficiently. (1)


People with diabetes either do not produce enough insulin or cannot properly use the insulin that their bodies produce. Insulin is a hormone that is needed to convert sugar, starches and other food into energy needed for daily life. As a result, glucose or sugar builds up in the bloodstream. Today, it is believed that chromium helps insulin bring glucose from the blood into the cells for energy.


Chromium is now generally recognized to play an important role in glucose and lipid metabolism. Chromium supplementation has the effect of normalizing blood sugar levels. Elevated blood sugar, or hyperglycemia, responds positively to chromium supplementation. Hyperglycemic patients given chromium after receiving a dose of glucose, or simple sugar, experienced a drop in blood sugar levels, while patients with low blood sugar, or hypoglycemia, experienced a normalization of their blood sugar levels after receiving chromium. (2)


Supplementation of chromium often leads to significant improvements in glucose tolerance, serum lipids including high-density lipoprotein cholesterol, insulin and insulin binding. Chromium also tends to normalize blood sugar levels.

The good natural source of chromium is brewer's yeast. It's also found in small amounts in egg yolk, whole-grain breads and cereals, brown rice, potatoes, broccoli, beef, liver, mushrooms, peanuts, and some spices. Dietary intakes of chromium cannot be reliably determined because the content of the mineral in foods is substantially affected by agricultural and manufacturing processes. For adults, a safe and healthy amount of chromium is considered to be between 50 and 200 mcg per day.


Chromium is a difficult mineral to absorb. Figures range from 0.5-3% absorption for the inorganic chromium salts. The organic complexes of chromium are absorbed better, at about 10-20%. Enhancing the mineral's absorption are vitamin C and niacin.


The dietary chromium intake of most individuals is considerably less than the suggested safe and adequate intake. Consumption of refined foods, including simple sugars, exacerbates the problem of insufficient dietary chromium since these foods are not only low in dietary chromium but also enhance additional chromium losses. Chromium losses are also increased due to pregnancy, strenuous exercise, infection, physical trauma and other forms of stress.