PerFem Forte™ - References

I Product Info I Ingredients
I Recommended Use
I Clinical Trials
I Research Brief
I References

Low USA domestic & international


Indication: menopausal syndrome, hormonal imbalance, cardio-vascular and nervous system support, prevention of osteoporosis and cancer of the female reproductive organs.

Actions: normalizes  the balance of female hormones, relieves symptoms of menopause, antioxidant defense, prevents aging, promotes healthy nervous and  cardiovascular systems, increases endurance and work capacity, has a beneficial impact on appearance.

Ingredients (per 1 packet): Vitamin E (as d-alpha-tocopheryl succinate) - 15 IU, Thiamin (as thiamin mononitrate) - 1 mg,  Riboflavin - 1 mg, Niacin (as niacinamide) - 10 mg, Vitamin B6 (as pyridoxine HCl) - 3 mg, Folate - 200 mcg, Vitamin B12 (as cyanocobalamin) - 3 mcg, Selenium (as selenium + GMP™) - 35 mcg,  Fermented (aglycone) VDF Isoflavones™ (from organic GMO-Free soybean extract and GMO-Free red clover extract (aerial parts))- 25.5 mg, Black cohosh (Cimicifuga foetida) (12:1) root extract [(8% triterpene glycosides (as 27-deoxyactein)] (equivalent to 150 mg of crude herb) - 12.5 mg.


PerFem Forte™ - References:

1. Perloff WH. Treatment of the menopause. Am J Obstet Gynecol 1949;58:684-94.

2. Grant JE, Veldee MS, Buchwald D. Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome. J Am Diet Assoc 1996;96:383-6.


3. Brown WV. Niacin for lipid disorders. Postgrad Med 1995;98:185–93 [review].


4.  Guyton JR. Effect of niacin on atherosclerotic cardiovascular disease. Am J Cardiol 1998;82(12A):18U–23U [review].


5. Bottiglieri T, Reynolds EH, Laundy M. Folate in CSF and age. J Neurol Neurosurg Psychiatry 2000; 69: 562


6. Homocysteine Lowering Trialists‘ Collaboration: Lowering blood homocysteine with folic acid based supplements: metaanalysis of randomised trials. BMJ 1998;316:894-8.


7. Wu K, Helzlsouer KJ, Comstock GW, et al. A prospective study on folate, B12, and pyridoxal 5’-phosphate (B6) and breast cancer. Cancer Epidemiol Biomarkers Prev 1999;8:209-17.


8. Peretz A, Néve J, Desmedt J, et al. Lymphocyte response is enhanced by supplementation of elderly subjects with selenium-enriched yeast. Am J Clin Nutr 1991;53:1323-8.


9. Clark LC, Combs GF, Turnbull BW, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. JAMA 1996;276:1957-63. Published erratum appears in JAMA 1997;277:1520.


10. Van de Weijer PHM, Barentsen R. Isoflavones from red clover (Promensil®) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas 2002;42:187-93.


11. Nestel PJ, Pomeroy S, Kay S, et al. Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women.


12. Helena J. Teede; Barry P. McGrath; Lakmini DeSilva; Marja Cehun; Andriana Fassoulakis; Paul J. Nestel. A Placebo-Controlled Study in Men and Postmenopausal Women. Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:1066.


13. J Clin Endocrinol Metab 1999;84:895-8. ACOG Practice Bulletin. Clinical Management Guidelines for Obstetrician-Gynecologists. Use of botanicals for management of menopausal symptoms. Obstet Gynecol 2001;97:suppl 1-11.


14. International Journal of Cancer, April 1, 2007.