ShieldsUp™ TR - Research Brief
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||I Clinical Trials
||I Research Brief
Indication: body‘s antioxidant defense, cardiovascular disease and cancer prophylaxis, prophylaxis of aging.
Actions: potent antioxidant, prevents free radical damage, strengthens the immune system, helps to slows down the aging process.
Ingredients (per 1 tablet): Vitamin A (100% as natural beta-carotene) - 2,500 IU, Vitamin C (as ascorbic acid, calcium ascorbate, ascorbyl palmitate, acerola 4:1 fruit extract, rose hips powder) - 50 mg, Vitamin E (as d-alpha-tocopheryl succinate) - 50 IU, Selenium (as selenium + GPM) - 50 mcg, OPC (oligometric proanthocanidins from 95% grape seed extract) - 25 mg, Resveratrol (from Polygonum cuspidatum root extract) - 2 mg, Green tea leaf extract - 35 mg, High-ORAC blend - 40 mg: Green tea extract (97% total polyphenols), grape seed extract, apple powder, blueberry powder, broccoli powder, cranberry powder, kale powder, orange powder, prune powder, raspberry powder, spinach powder, strawberry powder, and blueberry extract.
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ShieldsUp™ TR - Research Brief:
In the early ‘90s, after wine was pinpointed as the probable answer to the “French paradox,” researchers realized that the resveratrol content of wine might be the secret ingredient behind the healthy heart effects attributed to it.
The “French paradox” says that a person can eat a lot of fat, yet not get heart disease. Why? One of the reasons is that the wine they drink contains resveratrol, which is a powerful antioxidant. By now, many people have heard that oxidized low-density lipoprotein (LDL) is a problem in heart disease.
One of the serious complications of free radical damage is hardening and thickening of arteries. A “vicious cycle” of radicals, artery damage, and narrowing due to scar tissue that, in turn, promotes more free radical activity and more damage, has been described. (8)
Resveratrol’s antioxidant action helps stop free radical damage and opens the arteries by enhancing nitric oxide. Nitric oxide is a critical component of heart/artery function. It allows blood vessels to “relax,” which enhances blood flow. In a recent study, a high-cholesterol diet decreased nitric oxide by about a third. Resveratrol supplements significantly reversed the trend. (9)
Resveratrol also stops the proliferation of cells in blood vessels that narrow the arteries (10), and it also keeps blood cells from sticking together. Both are very important for preventing heart attacks.
It was shown recently that resveratrol possesses a “novel mechanism” for scavenging radicals. Although the research is very preliminary, studies indicate that resveratrol may be particularly important for those at risk for Alzheimer’s, or those who have it. It is theorized that free radicals might initiate the process that leads to the disease. (11)
The study from China showed that resveratrol reversed the signs of inflammatory response to spinal cord injury. It’s possible that if a person regularly takes supplemental resveratrol, they will be more likely to withstand a stroke or other injury to the brain. This has been demonstrated in rodents pretreated 21 days with resveratrol. Less brain damage occurred post-stroke. (12)
Cancer is, perhaps, the most dynamic area of resveratrol research. It has solid evidence showing that resveratrol not only prevents cancer, it’s being proposed as an additional treatment. (13,14)
In a widely publicized report, researchers at Harvard Medical School and BIOMOL Research Laboratories have demonstrated that resveratrol activates a “longevity gene” in yeast that extends life span by 70%. The effects mimic those of calorie restriction, the only proven way of extending maximum life span. Resveratrol activates one of the same “sirtuin” genes as calorie restriction. Although the research has only been done in yeast, flies and worms so far, humans have their own version of the same life span-extending gene.
One of the known causes of aging and death is that older cells lose their ability to perfectly replicate DNA in every new cell. DNA “mistakes” accumulate and allow little pieces of DNA to become active and print themselves out, so creating a type of “DNA debris” that eventually stops a cell from functioning.
Resveratrol reduces the frequency of “DNA debris” by 60% through the longevity gene that it stimulates.
Research has uncovered a diverse range of activities that may make resveratrol one of the most useful agents ever discovered for a wide range of human health problems.
In a study published in Free Radical Research (7), resveratrol was put to the test against vitamin E and a synthetic antioxidant. All three were very good at scavenging artery-damaging radicals, but resveratrol emerged as the best defense against certain types of radicals. This points out the importance of using a multi-approach to antioxidants.
Resveratrol represents a novel solution to many common problems encountered by aging humans. (15)