Gymnema (Gymnema sylvestre) is natural herb ingredient of Reglucol™
Gymnema (Gymnema sylvestre) is another exclusive ingredient in Reglucol™ formula. Gymnema has been used successfully in Indian ayurveda medicine for more than 2,000 years. The Indian name of this plant is translated as “sugar destroyer”.
Gymnema increases the activity of the enzymes, responsible for the sugar metabolism; controls blood sugar levels.
Gymnema extract contains gymnemic acid that has the ability to decrease sugar transfer from intestines to the bloodstream, and gurmarin that decreases taste bud functions.
Gymnema decreases sugar cravings, helps to suppress the appetite, and as a result, promotes weight control.
While it is still being studied, and the effects of the herb are not entirely known, the herb has been shown to reduce blood sugar levels when used for an extended period of time. Additionally, Gymnema reduces the taste of sugar when it is placed in the mouth, thus some use it to fight sugar cravings. From extract of the leaves were isolated glycosides known as Gymnemic acids, which exhibit anti-sweet activity.(1)
This effect, however, is short-lived, lasting a mere fifteen minutes. Some postulate that the herb actually reduces cravings for sugar by blocking sugar receptors in the tongue, but no scientific studies have supported this hypothesis. It is currently being used in an all natural medication for diabetes with other ingredients such as cinnamon, chromium, zinc, biotin, banaba, huckleberry and bitter melon.
The active ingredient is thought to be gurmenic acid which has structure similar to saccharose. Extracts of Gymnema is not only claimed to curb sweet tooths but also for treatment of as varied problems as hyperglycemia, obesity, high cholesterol levels, anemia and digestion. According to the Sushruta of the Ayurveda it helps to treat Madhumeha ie glycosuria.
In 2005, a study made by King’s College, London, United Kingdom, showed that a water-soluble extract of Gymnema Sylvestre, caused reversible increases in intracellular calcium and insulin secretion in mouse and human β-cells when used at a concentration (0.125 mg/ml) without compromising cell viability. Hence forth these data suggest that extracts derived from Gymnema Sylvestre may be useful as therapeutic agents for the stimulation of insulin secretion in individuals with T2DM.(2)
Reglucol™ contains standardizes Gymnema leaf extract (6:1) (25% gymnemic acids).
- AD kinghorn and CM Compadre. Less common high-potency sweeteners. In Alernative Sweeteners: Second Edition, Revised and Expanded, L O'Brien Nabors,Ed., New York, 1991. ISBN 0-8247-8475-8
- H Asare-Anane, GC Huang, SA Amiel, PM Jones & SJ Persaud (2005) Poster Presentations - Stimulation of insulin secretion by an aqueous extract of Gymnema sylvestre: role of intracellular calcium. Endocrine Abstracts, Volume 10 DP1.