Exclzyme® EN - Research Brief

I Product Info I Ingredients I Recommended Use I Clinical Trials I Research Brief I References


Indication: enzymatic deficiency, indigestion, dysbolism, degenerative changes in joints, increased blood viscosity, inflammations, traumas, wounds, postoperative recovery period.

Actions: improves digestion, regulates metabolism, has an anti-inflammatory and analgetic effect, has immunomodulatory, antiaggregatory, and fibrinolytic action, stimulates enzyme activity, speeds up the wound healing.

Ingredients (per 1 tablet):

Exclzyme®EN – 250 mg (30,000 EU): Peptizyme SP®EN, protease, papain, bromeline, amylase, lipase, rutin, amla (Emblica Officinalis).


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Exclzyme® EN - Research Brief:

What functions do enzymes carry out inside our body?

More then 3000 enzymes provide a wide range of different vital functions in our body. One of such functions is digestion, carried out by:
• Protease - breaks down protein.
• Lipase - breaks down fats.
• Amylase - breaks down carbohydrates.

Out of three listed enzymes, Amylase participates practically only in digestion, and Protease and Lipase have systemic functions. Systemic enzymes are those that are essential not just for digestion, but throughout the whole body in every system and organ. 

Major Functions of Systemic Enzymes:
Anti-inflammatory function
Enzymes are the first line of defense against inflammation. (1,2,3)
Inflammation is a reaction by the immune system to an irritation. For example: you have an injured right knee. The immune system, sensing the irritation in the knee, creates a protein chain called a Circulating Immune Complex (CIC), tagged specifically for that right knee. This CIC floats down to the right knee and causes pain, redness and swelling - the classic signs of inflammation. This, at first, is a beneficial reaction; it warns us that a part of ourselves is hurt and needs attention. But, inflammation is self-perpetuating, it creates an irritation that in response, the body makes CIC's for.

The non-steroid Anti Inflammatory Drugs (such as Aspirin, Ibuprofen, Celebrex, Viox, and etc.) all work by keeping the body from making the CIC's. This ignores the fact that some CIC's are vital for our life, like those that maintain the intestinal lining and keep the kidneys functioning. Not to mention the fact that they, along with acetaminophen, are highly toxic for the liver. Every year 20,000 Americans die from these over the counter drugs and another 100,000 will end up in the hospital with liver damage, kidney damage or intestinal bleeding caused by the side effects of these drugs. (4,5)

Systemic enzymes are perfectly safe and free of dangerous side effects. They can see the difference between the good CIC's and the bad ones. This is due to the fact that hydrolytic enzymes are lock and key mechanisms and their "teeth" will only fit over the bad CIC's, instead of preventing the creation of all CIC's, systemic enzymes just "eat" the bad ones and in so doing, lower inflammation everywhere. (6)

Anti Fibrosis and Blood Cleansing functions
As we grow old, enzymes production is slowed down in our body. This is because we make a finite amount of enzymes in a lifetime and we use up a good deal of them by the time we reach 40's. As a result the repair mechanism of the body goes out of balance and has nothing to reduce the over abundance of fibrin it deposits in every thing from simple cuts, to the inside of our internal organs and blood vessels. This is when most women begin to develop things like fibrocystic breast disease, uterine fibroids, endometriosis, and we all grow arterial sclerotic (scar tissue) plaque, and have fibrin beginning to spider web its way inside of our internal organs reducing their size and function over time. This is why as we age our wounds heal with thicker, less pliable, weaker and very visible scars.

Cystic Fibrosis patients have virtually no enzyme production; children usually don’t make it past their 20’s before they die of the restriction and shrinkage in the lungs from the formation of fibrosis or scar tissue.
Enzymes posses a unique ability to eat scar tissue and fibrosis. (7)

If we replace the lost enzymes we can control and reduce the amount of scar tissue and fibrosis our bodies have. As physicians in the US are now discovering, even old scar tissue can be “eaten away” from surgical wounds, pulmonary fibrosis, kidney fibrosis and even keloids years after their formation. 

The blood is not only the river of life, it is also the river through which the cells and organs dispose of their garbage and dead material. Enzymes improve circulation by eating the excess fibrin that causes blood to get thick, creating the perfect environment for the formation of clots. All of this material is supposed to be cleared by the liver the first time it goes through but given the sluggish and near toxic states of everyone's liver these days that seldom happens. So they remain in the blood waiting for the liver to have enough free working space and enough enzymes to clean up the trash out of the blood. This can take days, and in some cases, weeks! (8)

When systemic enzymes are taken, they stand ready in the blood and take the strain off of the liver by:
1. Cleaning excess fibrin from the blood and reducing the stickiness of blood cells. These two actions minimize the leading causes of stroke and heart attack causing blood clots.
2. Breaking dead material down small enough that it can immediately pass into the bowel.

Immune System Modulating
Enzymes are adaptogenic, seeking to restore a steady state to the body. (9) When the immune system is running low we become susceptible to infectious disease, enzymes help us strengthen the immune system. When it’s hyperactive, then the system creates antibodies that attack its own tissues (as in the auto-immune diseases of MS, Rheumatoid Arthritis, and Lupus). Here the enzymes would tone down immune function and eat away at the antibodies the immune system is making to attack its own tissue.

Even when the person is healthy, the organism frequently do not produce the sufficient amount of enzymes to support normal health living. And if the organism is weakened or overloaded, the demand for enzymes increases dramatically.

In various diseases, traumas and inflammations, in order to get rid of products of metabolism rapidly and effectively, to release space for new cells and to accelerate the healing process, the increased amount of system enzymes required – much greater than an organism can produce.
The proteolytic enzymes are a large group of enzymes, which break down protein. In a human body proteolytic enzymes are produced by pancreas. In the body, proteolytic digestive enzymes are produced in the pancreas, but supplemental forms of enzymes may come from fungal or bacterial sources, extraction from the pancreas of livestock animals (trypsin/chymotrypsin) or extraction from plants (such as Papain from the papaya and Bromelain from pineapples).

The scientific evidence supports the use of proteolytic enzyme supplements for enhancing digestive function and for speeding recovery from injury/surgery and reducing swelling/bruising, for benefits in autoimmune diseases and food allergies.
One of the most important benefits of supplemental enzyme therapy is to improve the effect of other medical products and to reduce their side effects.