Una de Gato GP - Research Brief
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Indication: decreased immune response, weakened organism, gastrointestinal tract mucous lining damage, tumor prevention.
Actions: potent antioxidant, adaptogen, strengthens the immune system, has anti-inflammatory, antibacterial, antiviral activity, lowers the risk of developing tumors, helps to detoxify the body.
Ingredients (per one capsule):
Cat’s Claw (Uncaria tomentosa (Willd.) DC) (4:1 bark extract standardized to 3% total oxindole alkaloids; equivalent to 1400 mg of crude herb) - 350 mg.
Low USA domestic & international
Una de Gato GP - Research Brief:
Viral diseases are an increasing worldwide health concern. As a consequence, the discovery of new natural antiviral agents is important more than ever.
Cat's Claw (Uncaria tomentosa, "Uña de gato") is widely used in South America for treatment of gastritis, arthritis, cancer and inflammatory conditions. Recent literature reports cytostatic, antiproliferative, anti-inflammatory, and anti-mutagenic properties of extracts of the plant. (1)
The use of cat's claw dates back to the Inca civilization. For hundreds of years the Indian tribes have used the inner bark of the tree to prepare a medicinal tea. The native healers use cat's claw to treat asthma, inflammations of the urinary tract, arthritis, rheumatism; to recover from childbirth; as a kidney cleanser; to cure deep wounds; to control inflammation and gastric ulcers; and for cancer.
Una de gato is considered a sacred plant among the Ashaninkas and other indigenous Peruvian Amazonian tribes. For centuries the miraculous healing properties of Cat's Claw were secret, known only to the shamans of the Amazon, who considered that the plant have life-giving properties.
In the early 1970's an Austrian researcher, Klaus Keplinger was introduced to medicinal plants used by the Asháninka Indians of Peru. In those days Uncaria tomentosa was still completely unknown to Western medicine. According to Keplinger, the herb serves as a means of "regulating the physical and spiritual worlds" for these tribal groups. (2)
Keplinger began studying the properties of una de gato and was granted US patents for isolating plant's major active constituents - oxindole alkaloids. In July 1989 was issued U.S. Patent No 4,844,901, and a second patent, No. 4,940,725, was issued in July 1990.
There are six oxindole alkaloids most prevalent in the Cat's Claw bark, known as: isopteropodine, pteropodine, mitraphylline, isomitraphylline, rynchophylline, and isorynchophylline.
The patent documents describe four of these alkaloids (isopteropodine, pteropodine, isomitaphylline, and isorynochophylline) as "proven suitable for unspecified stimulation of the immune system." The most immunologically active alkaloid, according to the patent is lsopteropodine.
Ryncophylline has been shown in laboratory testing to display an ability to inhibit platelet aggregation and thrombosis. This means ryncophylline may be useful in the prevention of stroke and reducing the risk of heart attack by lowering blood pressure, improving circulation, and inhibiting both the formation of plaque on the arterial walls and formation of blood clots in the vessels of the brain, heart and arteries.
Cat’s Claw contains other beneficial constituents including triterpenes, proanthocyanidins, polyphenols, glycosides, and the plant sterols beta-sitosterol, stigmasterol and campesterol.
Results from animal studies and reports of human cases show that cat's claw have anti-inflammatory effects for individuals with osteoarthritis and rheumatoid arthritis, although the mechanism of action is still not absolutely clear.
It is considered that cat's claw is able to enhance overall immunity while increasing stamina and energy in patients who suffer from physical and mental exhaustion due to an overactive or stressful lifestyle. (3)
Una de Gato can be used as a non-specific immunomodulating agent in viral illnesses and cancer, and it may also have potential as an immunomodulating adaptogen in aging. (4)
In one small human study and several animal studies, taking cat's claw may have promoted the repair of DNA damaged by chemotherapy or radiation.
Oxindole alkaloids stimulate the phagocytotic activity of the macrophages.
The oxindole alkaloids increase or reduce the reactivity of the immune system, depending on the initial status. These constituents can thus stimulate a weak immune system and suppress an over-reactive immune system.
Cat's claw is also thought to have anticancer activities and lab results demonstrated growth inhibitory effects on glioma and neuroblastoma cells. (7)
Italian researchers reported in a 2001 in vitro study that cat's claw directly inhibited the growth of a human breast cancer cell line by 90%. (8)
There are 34 species of the genus Uncaria, but Uncaria tomentosa offers the most promise as a therapeutic agent.
Consumers should check the Cat's Claw bottles they buy for "Uncaria tomentosa" and choose from a reputable company.