Osteo Complex - Research Brief

I Product Info I Ingredients
I Recommended Use
I Clinical Trials
I Research Brief
I References

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Indication: osteoporosis prophylaxis, inflammatory and degenerative changes in the joints, bone fractures, nail and hair fragility.

Actions: strengthens bones, ligaments and joints, the source of bioavailable calcium and manganese, prevents osteoporosis, reduces joint pain and inflammation, helps to rehabilitate the joint cartilage, normalizes the production of synovial fluid, strengthens teeth, nails and hair.

Ingredients (per 1 tablet):

Vitamin C (as ascorbic acid) - 10 mg, Calcium (as dicalcium phosphate) - 100 mg, Manganese (as manganese sulfate) - 0.3 mg, Glucosamine HCL – 250 mg, Proprietary Blend - 58.5  mg:  Boswellia extract (Boswellia serrata)(gum exude), Bromelain (from Ananas comosus), Nettle (Urtica dioica) leaf.

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Osteo Complex - Research Brief:

Did you know that the human body has 143 different joints? Acting as hinges, levers and shock absorbers, synovial joints allow us to jump, dance, climb, sit and walk. Joints are designed to hold bones close together while still allowing them freedom of movement.

The whole of a synovial joint is contained by a ligamentous sac, the joint capsule or articular capsule.

synovial_joint

The surfaces of the two bones at the joint are covered in cartilage. Of all the layers, it has the highest concentration of collagen and the lowest concentration of proteoglycans, making it very resistant to shear stresses. Deeper than that is an intermediate layer, which is mechanically designed to absorb shocks and distribute the load efficiently. The deepest layer is highly calcified, and anchors the articular cartilage to the bone.
The synovium is a membrane that covers all the non-cartilaginous surfaces within the joint capsule. It secretes synovial fluid into the joint, which nourishes and lubricates the articular cartilage. The synovium is separated from the capsule by a layer of cellular tissue that contains blood vessels and nerves.

Articular cartilage forms a cap at the end of the bones. This cartilage absorbs shock while allowing bones to easily slip and slide across each other during motion. That’s because most of the cartilage consists of water - in fact, it’s 65 to 80 percent water! The balance is made up of collagen and proteoglycans, which give cartilage its cushioning ability. 

Cartilage is composed of molecules known as proteoglycans, which are deposited within a matrix of collagen fibers. This complex traps water and helps give cartilage its flexibility, resiliency, and resistance to compression. Proteoglycans are a combination of protein and carbohydrate molecules. Higher levels of glucosamine within the cartilage-producing cells (chondrocytes) are critical for production of adequate amounts of proteoglycans. 
By helping to repair and rebuild the cartilage matrix, glucosamine can actually support healthy joint function.

Glucosamine hydrochloride demonstrates more stability, purity, and higher concentration when compared to glucosamine sulfate. During the preparation of glucosamine sulfate, sodium and potassium are added, and about 83 percent of glucosamine hydrochloride is actual glucosamine while only about 63 percent of glucosamine sulfate is actual glucosamine. Therefore, one gets more glucosamine per capsule form glucosamine hydrochloride than from glucosamine sulfate.