Osteo Complex - References

I Product Info I Ingredients
I Recommended Use
I Clinical Trials
I Research Brief
I References

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Indication: osteoporosis prophylaxis, inflammatory and degenerative changes in the joints, bone fractures, nail and hair fragility.

Actions: strengthens bones, ligaments and joints, the source of bioavailable calcium and manganese, prevents osteoporosis, reduces joint pain and inflammation, helps to rehabilitate the joint cartilage, normalizes the production of synovial fluid, strengthens teeth, nails and hair.

Ingredients (per 1 tablet):

Vitamin C (as ascorbic acid) - 10 mg, Calcium (as dicalcium phosphate) - 100 mg, Manganese (as manganese sulfate) - 0.3 mg, Glucosamine HCL – 250 mg, Proprietary Blend - 58.5  mg:  Boswellia extract (Boswellia serrata)(gum exude), Bromelain (from Ananas comosus), Nettle (Urtica dioica) leaf.

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Osteo Complex - References:

1. Department of Health (2004) At least five a week - evidence on the impact of physical activity and its relationship to health - a report from the Chief Medical Officer
2. Department of Health (2005) Choosing Activity: a physical activity action plan
3. Delafuente JC. Glucosamine in the treatment of osteoarthritis. Rheum Dis Clin North Am. 2000 Feb; 26(1): 1-11.
4. Rindone JP, Hiller D, Collacott E, Nordhaugen N, Arriola G. Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee. West J Med. 2000 Feb; 172(2): 91-4.
5. Chevalley T., Rizzoli R., Nydegger V., et al. Effects of calcium supplements on femoral bone mineral density and vertebral fracture rate in vitamin D-repleted elderly patients. Osteoporosis Int. 1994;4:245-52.
6. Dawson-Hughes B. Calcium, vitamin D and vitamin D metabolites. Osteoporosis 1996. Ed. S.E. Papapoulos et al. Elsevier. Amsterdam, Lausanne, New York. 1996; 299-303.
7. Safayhi H, Mack T, Saieraj J, et al. Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J Pharmacol Exp Ther 1992;261:1143-6.
8. Singh GB, Atal CK. Pharmacology of an extract of salai guggal ex-Boswellia serrata, a new non-steroidal anti-inflammatory agent. Agents Actions 1986;18:407-12.
9. Reginster JY, Deroisy R, Rovatti LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet 2001; 357:251-256. )
10. Müller-Fassbender H, Bach GL, Haase W, Rovati LC, Setnikar I. Glucosamine sulfate in osteoarthritis of the knee. Osteoarthritis Cartilage 1994; 2:61-69.
11. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7.