Norwegian Kelp GP - Clinical Trials

I Product Info I Ingredients
I Recommended Use
I Clinical Trials
I Research Brief
I References

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Indication: thyroid gland hypofunction, residence in endemic regions, weakened immunity, inertia, apathy, increased body mass, premenstrual syndrome, decreased skin elasticity, nail fragility, hair loss.

Actions: source of organic iodine, improves metabolism, stimulates thyroid gland function, normalizes endocrine gland function, increases energy levels, promotes detoxification, lowers the risk of developing tumors.

Ingredients (per 1 tablet):

Iodine (from Norwegian kelp) - 150 mcg, Norwegian kelp (0.1% iodine) (Ascophylum nodosum) - 150 mg.

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Norwegian Kelp GP - Clinical Trials:

The most significant benefits of fucoidan pertain to its ability to strengthen the immune system. In a number of in vitro and animal studies, it has inhibited coated viruses. Experiments have suggested that fucoidan may not only inhibit the initial stages of viral infection, such as attachment to and penetration into host cells, but also the later replication stages after virus penetration. (7)


In a  pilot study by University of Chicago researchers researchers tested fucoidan, to see whether they could prevent herpes infections. Fifteen patients with active herpes-type infections (including herpes simplex virus types 1 and 2, herpes zoster or Epstein bar virus) and six subjects with latent infections, consumed oral doses of fucoidan. Ingestion of fucoidan was associated with increased healing rates in patients with active infections. In addition, patients with latent infections remained asymptomatic while ingesting fucoidan. (8)

 

The ability of fucoidan to inhibit the herpes virus may explain, in part, why there is a much lower incidence of herpes simplex virus type 2 infections in Japan, compared with the west, in that the Japanese diet contains a high consumption of fucoidan-containing seaweed.


Research that digs deeper into the mechanism of action of fucoidan indicates its reach extends far beyond simply inhibiting viruses. It has been shown to influence the immune system in a number of ways. First, fucoidan has stimulated an increase in levels of a cytokine known as interferon gamma. Cytokines are proteins produced by white blood cells and are important in regulating immunity. Interferon gamma is a cytokine that generates increased immune activity during infections and cancer states. (9, 10)

 

Another explanation for the immune-enhancing properties of fucoidan involve its ability to stimulate natural killer cells, which play an important part in the immune response by destroying cells infected with viruses. Natural killer cells are also vital to seeking out and destroying tumor cells and are a major defense against malignancies. In a recent study, researchers investigated the effects of fucoidan on the tumor growth of mouse leukemia cells and on T cell-mediated immune responses in mice. The animals were fed a diet containing 1 percent fucoidan for 10 days and subcutaneously inoculated with leukemia cells. Thereafter, the mice were fed with the diet containing fucoidan for 40 days. In mice receiving the fucoidan, tumors were inhibited by 65.4 percent. Additionally, natural killer cell activity significantly increased in the fucoidan-fed mice compared to animals fed a normal diet. (11)

 

A French research study in 2002 showed that F-fucoidan can inhibit hyperplasia (abnormal cell overgrowth) in rabbits.

Smooth muscle cell (SMC) proliferation within the intima is regulated by heparan sulfates. We studied a low molecular weight (LMW) fucoidan (sulfated polysaccharide from brown seaweed) on SMC proliferation in vitro and intimal hyperplasia in vivo. In vitro study revealed that LMW fucoidan reduces rabbit SMC proliferation and is internalized in SMC perinuclear vesicles. On rabbit iliac arteries perfused in vivo with fluorolabeled LMW fucoidan after angioplasty, the labeling was mainly located on sites of injury. Pharmacokinetic studies showed that LMW fucoidan exhibited in rats an elimination half-life of 56±25 minutes (n=8) after intravenous administration and a constant plasma rate for 6 hours after intramuscular administration. After stent implantation in their iliac arteries, rabbits were also treated with LMW fucoidan (5 mg/kg IM twice a day). Histomorphometric analysis at day 14 indicated that LMW fucoidan reduced intimal hyperplasia by 59% (1.79±0.4 versus 0.73±0.2 mm2, P<0.0001) and luminal cross-sectional area narrowing by 58% (0.38±0.08 versus 0.16±0.04, P<0.0001). Blood samples showed no anticoagulant activity due to LMW fucoidan.

This natural polysaccharide with high affinity for SMCs and sustained plasma concentration markedly reduced intimal hyperplasia, suggesting its use for the prevention of human in-stent restenosis.  (12)

 

A Japanese research report in 2005 indicated that F-fucoidan can induce apoptosis (spontaneous, programmed, cancer cell death) in human lymphoma cell lines. (13)

 

Traditional oriental medicine has long held that the use of seaweeds reduces the risk of heart disease. Recent research sited by Dr. Zakir Romazanov in Neutriceuticals World (vol.2, No. 6) claims that certain elements in bladderwrack (Fucus vesiculosis) and rockweed (Ascophyllum nodosum) have the ability to lower blood plasma cholesterol levels, a key to heart health.

 

Fucoidan’s role as a natural anti-coagulant (blood thinner) also may explain its protective effects on the heart, blood vessels and other vital organs. Thus, fucoidan has been demonstrated to possess significant cardioprotective activity that may be of particular benefit to anyone with cardiovascular health conditions and/or for prevention of heart and blood vessel problems. (14)

 

Fucoidan has been demonstrated to have a number of other interesting properties. In one clinical trial, subjects with non-ulcer dyspepsia (indigestion) were given 1.5 to 4.5 mg/kg/day of oral fucoidan for two weeks. Symptoms of non-ulcer dyspepsia were relieved in the subjects given fucoidan. Researchers believe these results are explained by studies that have shown fucoidan can stop the ulcer-causing bacterium Helicobacter pylori from adhering to gastric cells. (15)

 

Researchers found that alginic acid, one of the important intercellular polysaccharides found in large brown algae like Kelp and Alaria, has detoxifying qualities.

The EPA's Environmental Toxicology Lab found that alginates could bind and eliminate both radionucleides such as Strontium 90 and heavy metals such as cadmium. They also discovered that Strontium already stored in the bones was re-secreted and bound by the alginates and safely passed through the intestines. Thus the remarkable kelps can help alleviate past as well as present toxic contamination. (16)