Gotu Kola GP - Clinical Trials

I Product Info I Ingredients
I Recommended Use
I Clinical Trials
I Research Brief
I References

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Indication: brain circulation impairment, impaired memory, dizziness, varicose veins, menopausal syndrome, sleep disturbance, nervousness, stress, wounds, burns, cuts, cosmetic surgery.

Main Actions: supports mental functions, memory and concentration, improves brain and peripheral circulation, helps to lower intracranial pressure, improves symptoms of varicose veins, speeds up healing processes, mild sedative effect.

Ingredients:(per 1 capsule):

standardized Gotu kola (Centella asiatica) leaf 12:1 extract (10% asiaticosides – 15 mg) (equivalent to 1800 mg of crude herb) - 150 mg.

 

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Gotu Kola GP - Clinical Trials:

Asiaticoside derived from the plant Centella asiatica is known to possess good wound healing activity. Enhanced healing activity has been attributed to increased collagen formation and angiogenesis. Since antioxidants have been reported to play a significant role in the wound healing process we studied the effect of asiaticoside on the levels of certain antioxidants in the wound so as to explore the possible involvement of such a mechanism in the asiaticoside induced wound healing. Asiaticoside application (0.2%, topical) twice daily for 7 days to excision-type cutaneous wounds in rats led to increased enzymatic and non-enzymatic antioxidants, namely superoxide dismutase (35%), catalase (67%), glutathione peroxidase (49%), vitamin E (77%) and ascorbic acid (36%) in newly formed tissues. It also resulted in a several fold decrease in lipid peroxide levels (69%) as measured in terms of thiobarbituric acid reactive substance. However, continued application for 14 days showed no significant difference in these antioxidants compared with their values in vehicle treated wound tissue. It appears from the present study that asiaticosides enhanced induction of antioxidant levels at an initial stage of healing which may be an important contributory factor in the healing properties of this substance. (4)

The object of this study was to evaluate the healing activity of CothylineTM, a new formulation comprising asiaticoside as the main ingredient in combination with antiseptic adjuvants. The study has two parts: (1) a clinical phase involving the observation of patients afflicted with soiled
wounds and chronic or recurrent atony which was resistant to the usual treatment, and (2) an experimental phase in which the healing action of Cothyline™ was evaluated by light and electron microscopic observation of the morphological changes that occurred in scarified guinea pig skin. Treatment of patients with Cothyline™ completely healed (64%) or improved (16%) the lesions under study. In the animal study, it was shown that changes occurred in the shape and size of the keratohyaline granules, a phenomenon observed during accelerated healing. (5)

Madecassol is an extract of Centella asiatica, a member of the Umbelliferae family. It contains madecassic acid, asiatic acid and asiaticoside. It has been used as a wound healing agent and for the prevention of cicatrization.
Madecassol has also been shown to have a preventive effect on burn and postoperative hypertrophic scars. It compares favorably in effectiveness with compression bandaging, and gives more lasting results than intralesional cortisone or radiation therapy. (6)

Ninety-four patients suffering from venous insufficiency of the lower limbs participated in a multicenter, double-blind versus placebo study. After randomization, they were allotted for a treatment period of two months to one of three groups: Titrated extract of Centella asiatica (TECA) 120 mg/day, TECA 60 mg/day, or placebo. A significant difference (p less than 0.05) in favor of TECA was shown for the symptoms of heaviness in the lower limbs and edema, as well as for the overall evaluation by the patient. The venous distensibility measured by a mercury strain gauge plethysmograph at three occlusion pressures was improved for the TECA groups but aggravated for the placebo group. The results showed a significant dose-related improvement in the treated groups. (7)

Preliminary studies showed Gotu kola ability to boost memory, overcome stress and tiredness.
Gotu kola has been used in traditional Ayurvedic medicine to treat anxiety.
In one clinical trial, scientists gave 40 healthy adults either a very high onetime dose of 12 g of Gotu kola or a placebo. Then they measured the subject’s startle responses with loud bursts of noise. After 60 minutes, the Gotu kola group displayed less than half the startle response of the control group. (8)

Two Indian studies reported that Gotu kola helped improve intelligence, general mental abilities, and behavior in mentally retarded children.

Interesting results were shown in animal study. Rats that ate Gotu kola every day for 14 days had three to 60 times better retention of learned behaviors than rats that took a placebo.