Chlorophyll Forte GP - Clinical Trials
|I Product Info||I Ingredients||I Recommended Use||I Clinical Trials||I Research Brief||I References|
Indication:overall health improvement, hypovitaminosis, susceptibility to allergic rashes, colds, inflammation of mucous lining of mouth, throat, stomach and duodenum, wounds, mucosal and skin ulceration, decreased lactation in breast feeding mothers.
Main Actions: supports the immune system of the body, provides anti-bacterial effect, improves mucus membranes condition, provides a wound healing effect, removes unpleasant mouth and body odors, increases the lactation in breast feeding mothers.Ingredients (per 1 capsule):
Sodium Copper Chlorophyllin - 50 mg.
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Chlorophyll Forte GP - Clinical Trials:
Several clinical trials «in vitro» revealed the ability of chlorophyll to neutralize free radicals. (9,10)
The research conducted on animals allowed to suggest that additional chlorophyll intake can decrease the damage caused by free radicals, chemical carcinogens and radiation. (11,12)
Residents of Qidong, People's Republic of China, are at high risk for development of hepatocellular carcinoma, in part from consumption of foods contaminated with aflatoxins. Chlorophyllin, a mixture of semisynthetic, water-soluble derivatives of chlorophyll has been shown to be an effective inhibitor of aflatoxin hepatocarcinogenesis in animal models by blocking carcinogen bioavailability.
In a randomized, double-blind, placebo-controlled chemoprevention trial, was tested whether chlorophyllin could alter the disposition of aflatoxin. One hundred and eighty healthy adults from Qidong were randomly assigned to ingest 100 mg of chlorophyllin or a placebo three times a day for 4 months. The primary endpoint was modulation of levels of aflatoxin-B1–N7-guanine adducts in urine samples collected 3 months into the intervention measured by using sequential immunoaffinity chromatography and liquid chromatography-electrospray mass spectrometry. This aflatoxin-DNA adduct excretion product serves as a biomarker of the biologically effective dose of aflatoxin, and elevated levels are associated with increased risk of liver cancer. Adherence to the study protocol was outstanding, and no adverse events were reported. Aflatoxin-B1-N7-guanine could be detected in 105 of 169 available samples. Chlorophyllin consumption at each meal led to an overall 55% reduction (P = 0.036) in median urinary levels of this aflatoxin biomarker compared with those taking placebo.
Thus, prophylactic interventions with chlorophyllin or supplementation of diets with foods rich in chlorophylls may represent practical means to prevent the development of hepatocellular carcinoma or other environmentally induced cancers. (13)
A couple of studies were published claiming that the consumption of 100-300 mg of chlorophyll per day can reduce the smell of urine and faeces in patients with fecal incontinence. (14,15)
The recent clinical research, conducted in Japan on patients suffering from trimethylaminuria, accompanied by repulsive smell, showed that after 3 weeks of oral intake of chlorophyllin (60 mg 3 times a day) the level of trimethylamine in the urine of the patients was markedly reduced. (16)
The investigations were carried out in the 40-th of the last centuries, demonstrated that the consumption of chlorophyllin slows down the growth of anaerobic bacteria during the treatment of open wounds («in vitro»), local use of chlorophyllin speeds up the healing process (animal trials), and highly effective for open wounds treatment in humans. (17)
By the end of 40ies, beginning of 50ies, the series of studies showed that the local use of chlorophyllin in patients with slow healing wounds, such as trophic ulcers and bedsores, is much more effective than widely used medications. (18,19)
Chlorophyll and chlorophyllin are absolutely safe remedy that is proven by more than 50 years history of clinical use. (17)