Camosten™ - Research Brief

I Product Info I Ingredients I Recommended Use I Clinical Trials I Research Brief I References

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Indication: bone and teeth strengthening, calcium deficiency, to prevent rickets and osteoporosis, bone fractures, caries, nail fragility, impaired neuromuscular transmission, pregnancy and lactation.

Actions: prevents osteoporosis, strengthens the bone tissues, promotes bone fracture healing, promotes normal growth and development of children, prevents rickets, strengthens the teeth, improves neuromuscular transmission.

Ingredients (per 1 packet – 6.6 g):

Vitamin D (as cholecalciferol) - 80 IU, calcium (as dicalcium phosphate and calcium citrate - 500 mg, magnesium (as magnesium citrate) - 200.0 mg, manganese (as manganese gluconate) - 0.2 mg.

Camosten™ - Research Brief:

Calcium
Calcium, the most abundant mineral in the human body, has several important functions. More than 99% of total body calcium is stored in the bones and teeth where it functions to support their structure.  (5)
The remaining 1% is found throughout the body in blood, muscle, and the fluid between cells. Calcium is needed for muscle contraction, blood vessel contraction and expansion, the secretion of hormones and enzymes, and sending messages through the nervous system.
A constant level of calcium is maintained in body fluid and tissues so that these vital body processes function efficiently.

It is important to get plenty of calcium in the foods you eat. Foods rich in calcium include diary products such as milk, cheese and yogurt, and leafy, green vegetables. The exact amount of calcium you need depends on your age and other factors. Growing children and teenagers need more calcium than young adults. Older women need plenty of calcium to prevent osteoporosis. People who do not eat enough high-calcium foods should take a calcium supplement.

Bone undergoes continuous remodeling, with constant resorption (breakdown of bone) and deposition of calcium into newly deposited bone (bone formation). The balance between bone resorption and deposition changes as people age. During childhood there is a higher amount of bone formation and less breakdown. In early and middle adulthood, these processes are relatively equal. In aging adults, particularly among postmenopausal women, bone breakdown exceeds its formation, resulting in bone loss, which increases the risk for osteoporosis (a disorder characterized by porous, weak bones).
Bones continue to add more mass until around age 30, when peak bone mass is reached. Because bone loss, like bone growth, is a gradual process, the stronger your bones are at age 30, the more your bone loss will be delayed as you age. Therefore, it is particularly important to consume adequate calcium and vitamin D throughout infancy, childhood, and adolescence. It is also important to engage in weight-bearing exercise to maximize bone strength and bone density (amount of bone tissue in a certain volume of bone) to help prevent osteoporosis later in life.
Weight bearing exercise is the type of exercise that causes your bones and muscles to work against gravity while they bear your weight.

 

Examples of weight bearing exercise: walking, running, dancing, aerobics, skating.


bones
Osteoporosis is a disorder characterized by porous, fragile bones. Osteoporosis is a serious public health problem for more than 10 million Americans, 80% of whom are women. Another 34 million Americans have osteopenia, or low bone mass, which precedes osteoporosis. Osteoporosis is a concern because of its association with fractures of the hip, vertebrae, wrist, pelvis, ribs, and other bones. Each year, Americans suffer from 1.5 million fractures because of osteoporosis. (6)

When calcium intake is low or calcium is poorly absorbed, bone breakdown occurs because the body must use the calcium stored in bones to maintain normal biological functions such as nerve and muscle function. Bone loss also occurs as a part of the aging process. A prime example is the loss of bone mass observed in post-menopausal women because of decreased amounts of the hormone estrogen. Researchers have identified many factors that increase the risk for developing osteoporosis. These factors include being female, thin, inactive, of advanced age, cigarette smoking, excessive intake of alcohol, and having a family history of osteoporosis. (7)
Researches show that calcium supplementation is essential for the osteoporosis prevention. (29, 30, 31)

Some observational and experimental studies indicate that individuals who eat a vegetarian diet high in minerals (including calcium, magnesium and potassium) and fiber, and low in fat, tend to have reduced blood pressure. (8, 9, 10)Findings from some clinical trials (a specific type of experimental study) used to evaluate the effects of one or more treatments/interventions in humans) indicate that an increased calcium intake lowers blood pressure and the risk of hypertension (high blood pressure). (11, 12)

Several studies, primarily observational in nature, have linked higher calcium intakes to lower body weights or less weight gain over time. (13, 14, 15)

Magnesium 
There are about 19 g of Mg in the average 70 kg adult body, of which approximately 65% is found in bone and teeth, and the rest is distributed between the blood, body fluids, organs and other tissue.  Magnesium is involved in the synthesis of protein, and it is an important co-factor in more than 300 enzymatic reactions in the human body, many of which contribute to the production of energy, and with cardiovascular functions.  While calcium affects muscle contractions, magnesium balances that effect and relaxes muscles.  Most of magnesium is inside the cell, and while iron is the central atom in hemoglobin, magnesium is the central core of the chlorophyll molecule in plant tissue

Vitamin D
Vitamin D (calciferol) is photosynthesized in the skin by the action of solar ultraviolet B radiation. Vitamin D comes in many forms, but the two major physiologically relevant ones are vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol) (Fieser and Fieser, 1959).
Vitamin D’s major biologic function in humans is to maintain serum calcium and phosphorus concentrations within the normal range by enhancing the efficiency of the small intestine to absorb these minerals from the diet
Vitamin D is essential for the efficient utilization of calcium by the body. (17)
There is plenty of scientific evidence that vitamin D has several different effects on immune system function. (18)

The active form of vitamin D plays a role in insulin secretion under conditions of increased insulin demand.  Limited data in humans suggests that insufficient vitamin D levels may have an adverse effect on insulin secretion and glucose tolerance in type 2 diabetes. (19, 20)

Adequate vitamin D levels may be important for decreasing the risk of high blood pressure.

Osteoporosis is most often associated with inadequate calcium intake.  However, a deficiency of vitamin D also contributes to osteoporosis by reducing calcium absorption.  While rickets and osteomalacia are extreme examples of vitamin D deficiency, osteopororsis is an example of a long-term effect of vitamin D insufficiency. Adequate storage levels of vitamin D help keep bones strong and may help prevent osteoporosis in older adults, in those who have difficulty walking and exercising, in post-menopausal women, and in individuals on chronic steroid therapy. (21, 22, 23)

Several studies suggest that a higher dietary intake of calcium and vitamin D correlates with lower incidence of cancer. (24, 25)

Since a large body of science shows vitamin D works closely with calcium and magnesium, it is best to take your vitamin D in combination with calcium and magnesium to maintain a proper balance.  Recent literature also shows most calcium supplements have too little vitamin D to be effective.  And some of them use synthetic vitamin D2.  A much better form is natural vitamin D3 which stays in your system longer and with more effect.

Camosten™ is a well balanced combination of the natural form of vitamin Dcholecalciferol, calcium and magnesium for the ultimate protection if your bones.